Search
pituitary adenylate cyclase-activating polypeptide; PACAP; contains: PACAP-related peptide; PRP-48; pituitary adenylate cyclase-activating polypeptide 27; PACAP-27; PACAP27; pituitary adenylate cyclase-activating polypeptide 38; PACAP-38; PACAP38 (ADCYAP1)
Function:
- plays a role in vagally-activated nocturnal gastric acid secretion (independent of gastrin)
- there is a distinct PACAP receptor in the anterior pituitary, but PACAP may share receptor with VIP in lung
- binding to its receptor activates G proteins & stimulates adenylate cyclase in pituitary cells
- interacts with ADCYAP1R1 (via N-terminal extracellular domain)
Structure:
- belongs to the glucagon family
- shares 68% sequence homology with vasoactive intestinal polypeptide (VIP) in 28 N-terminal amino acids
Compartment: secreted
Related
pituitary adenyl cyclase activating polypeptide [PACAP] receptor
General
secreted peptide
Properties
SIZE: entity length = 176 aa
entity length = 27-38 aa
MW = 19 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-24}
Important for receptor binding {150-158}
Database Correlations
OMIM 102980
UniProt P18509
Pfam PF00123
Entrez Gene 116
Kegg hsa:116
References
- Pisegna, J. In: Intensive Course in Geriatric Medicine &
Board Review, Marina Del Ray, CA, Sept 12-15, 2001
- UniProt :accession P18509