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Pittsburgh compound B [C11] (PIB)

Indication: 1) PET scan imaging of brain for Alzheimer's disease [1] 2) PET scan imaging of brain for cerebral amyloid angiopathy [2] Mechanism of action: 1) C11-labeled agent that binds fibrillar amyloid 2) does not distinguish amyloid plaques of Alzheimer's disease from vascular amyloid of cerebral amyloid angiopathy

General

benzothiazole radiopharmaceutical phenol amine

Database Correlations

PUBCHEM cid=2826731

References

  1. Archer HA et al, Amyloid load and cerebral atrophy in Alzheimer's disease: An 11C-PIB positron emission tomography study. Ann Neurol 2006, 60:145 PMID: 16802294
  2. Johnson K et al, Imaging of amyloid burden and distribution in cerebral amyloid angiopathy. Ann Neurol 2007, 62:229 PMID: 17683091
  3. Ly JV et al. 11C-PIB binding is increased in patients with cerebral amyloid angiopathy-related hemorrhage. Neurology 2010 Feb 9; 74:487. PMID: 20142615