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PIN2/TERF1-interacting telomerase inhibitor 1; liver-related putative tumor suppressor; Pin2-interacting protein X1; protein 67-11-3; TRF1-interacting protein 1 (PINX1 LPTL LPTS)
Function:
- microtubule-binding protein essential for faithful chromosome segregation
- mediates TRF1 & TERT accumulation in nucleolus & enhances TRF1 binding to telomeres
- inhibits telomerase activity
- may inhibit cell proliferation & act as tumor suppressor
- interacts with MCRS1, TERT, TERF1, NCL/nucleolin, & the telomerase RNA
- telomerase inhibitor
- binds TERT, TERF1
Structure:
- the TID (telomerase inhibiting domain) domain is sufficient to bind TERT & inhibit its activity the TBM domain mediates interaction with TERF1
- belongs to the PINX1 family
- contains 1 G-patch domain
Compartment:
- nucleus, nucleolus, chromosome, telomere
- centromere, kinetochore
- localizes in nucleoli, at telomere speckles & to the outer plate of kinetochores
- localization to the kinetochore is mediated by its central region & depends on NDC80 & CENPE
Alternative splicing: named isoforms=2
Expression:
- ubiquitous
- expressed at low levels
- not detectable in a number of hepatocarcinoma cell lines
General
nuclear protein
Properties
SIZE: entity length = 328 aa
MW = 37 kD
COMPARTMENT: cell nucleus
MOTIF: G-patch domain {26-72}
Telomerase inhibitory domain (TID) {254-328}
MOTIF: TBM {287-297}
Database Correlations
OMIM 606505
UniProt Q96BK5
Pfam PF01585
Entrez Gene 54984
Kegg hsa:54984
References
- Zhou XZ & Lu KP
The Pin2/TRF1-interacting protein PinX1 is a potent telomerase
inhibitor.
Cell 107:347-59, 2001
PMID: 11701125
- UniProt :accession Q96BK5