pilomatricoma; pilomatrixoma; calcifying epithelioma of Malherbe

A benign, solitary hair follicle tumor. Pathology: 1) cells resembling basal cell carcinoma 2) areas of epithelial necrosis 3) eosinophilic ghost cells 4) variable calcification 5) foreign body giant cell reaction in fibrous stroma Genetics: - some cases associated with beta-catenin mutations Clinical manifestations: - often occurs in childhood Complications: - rarely, malignant transformation to pilomatrix carcinoma

References

Stedman's Medical Dictionary 27th ed, Williams & Wilkins, Baltimore, 1999.

Databases & Images

OMIM 132600 image related to pilomatricoma