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pigment epithelium derived factor (PEDF, EPC-1, SERPINF1)
Function:
- neurotrophic for cerebellar granule cells
- inhibits microglial growth
- induces neuronal differentiation in retinoblastoma cells
- inhibitor of angiogenesis in cornea & vitreous, produced by retinal cells
- extracellular phosphorylation enhances antiangiogenic activity
Structure:
- shares homology with serpin family proteins but does not inhibit proteases
- N-terminus is blocked
- the N-terminal (AA 44-121) exhibits neurite outgrowth- inducing activity
- the C-terminal exposed loop (AA 382-418) is essential for serpin activity
- belongs to the serpin family
Compartment:
- secreted
- melanosome
Expression:
- retinal pigment epithelial cells
- blood plasma
- expressed in quiescent cells
Related
patatin-like phospholipase domain-containing protein 2 (adipose triglyceride lipase, desnutrin, transport-secretion protein 2, TTS2, TTS2.2, Ca+2-independent phospholipase A2, IPLA2-zeta, pigment epithelium-derived factor, PNPLA2, ATGL, FP17548)
SERPINF1 gene mutation
General
glycoprotein
phosphoprotein
serine protease inhibitor; serpin
Properties
SIZE: entity length = 418 aa
MW = 46 kD
MOTIF: signal sequence {1-19}
Ser phosphorylation site {S24}
Ser phosphorylation site {S114}
Ser phosphorylation site {S227}
N-glycosylation site {N285}
INHIBITS: serine protease
Database Correlations
OMIM 172860
UniProt P36955
Pfam PF00079
References
- Dawson DW et al
Pigment epithelium-derived factor: a potent inhibitor of
angiogenesis.
Science 285:245-8, 1999
PMID: 10398599