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Pick-1 protein
Function:
- binds to AMPA receptor & protein kinase C
Structure:
- PDZ domain of Pick-1 binds to the C terminus of the GluR2 & GluR3 subunits of the AMPA receptor
Interactions
molecular events
General
scaffold protein
Properties
COMPARTMENT: synaptic membrane
CELL: neuron
MOTIF: membrane region
PDZ domain
NAME: PDZ domain
References
- Sheng M.
Molecular organization of the postsynaptic specialization.
Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7058-61. Review.
PMID: 11416187
- Perez JL, Khatri L, Chang C, Srivastava S, Osten P, Ziff EB.
PICK1 targets activated protein kinase Calpha to AMPA receptor
clusters in spines of hippocampal neurons and reduces surface
levels of the AMPA-type glutamate receptor subunit 2.
J Neurosci. 2001 Aug 1;21(15):5417-28.
PMID: 11466413
Component-of
molecular complex