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pleckstrin homology [PH] domain
A group of related sequences 50-100 amino acids in length. PH-domains may be involved in interactions with the beta/gamma subunits of GTP-binding proteins &/or they may associate with phospholipids & promote association of signaling proteins with membranes. Proteins containing a PH-domain are generally cytoplasmic, but associate with the plasma membrane.
PH-domains are comprised of 2 roughly perpendicular anti-parallel beta sheets, followed by a C-terminal amphipathic alpha-helix.
Related
pleckstrin homology domain containing family
pleckstrin; platelet p47 protein (PLEK P47)
General
domain
peptide motif
References
- Musacchio A, Gibson T, Rice P, Thompson J, Saraste M.
The PH domain: a common piece in the structural patchwork of
signalling proteins.
Trends Biochem Sci. 1993 Sep;18(9):343-8. Review.
PMID: 8236453
- Pawson T
Protein modules and signalling networks
Nature 373:573 1995 (Notch)
PMID: 7531822