PH & SEC7 domain-containing protein 4 (pleckstrin homology & SEC7 domain-containing protein 4, exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B, telomeric of interleukin-1 cluster protein, PSD4, EFA6B, TIC)

Function: - guanine nucleotide exchange factor for ARF6-like protein - role in membrane recycling Structure: - contains 1 PH domain - contains 1 SEC7 domain Compartment: - cell membrane - accumulates in dynamic actin-rich membrane ruffles & microvilli-like structures Alternative splicing: named isoforms=2 Expression: - widely expressed - highest levels of expression in placenta, pancreas, spleen, thymus & peripheral blood

General

guanine nucleotide exchange factor (GDP/GTP dissociation stimulator, guanine nucleotide-releasing factor/protein, GNEF, GNDS, GDS) PH & SEC7 domain-containing protein

Properties

SIZE: MW = 116 kD entity length = 1056 aa MOTIF: sec7 domain SITE: 544-736 PH domain {776-892} coiled coil {921-976}

Database Correlations

UniProt Q8NDX1 PFAM correlations

References

UniProt :accession Q8NDX1