PH & SEC7 domain-containing protein 1 (pleckstrin homology & SEC7 domain-containing protein 1, exchange factor for ARF6, PSD, EFA6, KIAA2011, PSD1, TYL)

Function: - guanine nucleotide exchange factor for ARF6 Structure: - contains 1 PH domain - contains 1 SEC7 domain Alternative splicing: named isoforms=2 additional isoforms may exist Expression: isoform 2 is expressed in the brain

General

guanine nucleotide exchange factor (GDP/GTP dissociation stimulator, guanine nucleotide-releasing factor/protein, GNEF, GNDS, GDS) PH & SEC7 domain-containing protein

Properties

SIZE: entity length = 1024 aa MW = 110 kD MOTIF: proline-rich region SITE: 18-181 MOTIF: proline residue (SEVERAL) proline-rich region SITE: 432-466 MOTIF: proline residue (SEVERAL) glutamate-rich region {483-488} MOTIF: glutamate residue (SEVERAL) sec7 domain SITE: 512-706 PH domain {756-869} coiled coil {898-924}

Database Correlations

OMIM 602327 UniProt A5PKW4 PFAM correlations Kegg hsa:5662

References

UniProt :accession A5PKW4