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phosphotidylinositol phosphatase PTPRQ (receptor-type tyrosine-protein phosphatase Q, PTP-RQ, PTPRQ)
Function:
- phosphatidylinositol phosphatase
- required for auditory function
- may act by regulating the level of PtdIns(4,5)P2 (PIP2) level in the basal region of hair bundles
- can dephosphorylate a broad range of phosphatidylinositol phosphates, including PtdIns(3,4,5)P3 & most phosphatidylinositol monophosphates & diphosphates
- phosphate can be hydrolyzed from the D3 & D5 positions in the inositol ring
- has low tyrosine-protein phosphatase activity,however, the relevance of such activity in vivo is unclear
protein tyrosine phosphate + H2O protein tyrosine + phosphate
Structure:
- belongs to the protein-tyrosine phosphatase family receptor class 2A subfamily
- contains 18 fibronectin F3 modules
- contains 1 tyrosine-protein phosphatase domain
Compartment: membrane
Expression:
- in developing kidney, localizes to basal membrane of podocytes, beginning when podocyte progenitors can first be identified in the embryonic kidney (at protein level)
- expressed in lung & kidney
General
glycoprotein
membrane protein
phosphomonoesterase
Properties
SIZE: entity length = 2332 aa
MW = 261 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-35}
MOTIF: N-glycosylation site {N18}
fibronectin type III domain or F3 module {36-93}
N-glycosylation site {N94}
fibronectin type III domain or F3 module {98-192}
fibronectin type III domain or F3 module {197-289}
MOTIF: N-glycosylation site {N202}
fibronectin type III domain or F3 module {347-434}
MOTIF: N-glycosylation site {N394}
fibronectin type III domain or F3 module {439-531}
fibronectin type III domain or F3 module {514-606}
fibronectin type III domain or F3 module {607-700}
fibronectin type III domain or F3 module {707-796}
fibronectin type III domain or F3 module {801-891}
fibronectin type III domain or F3 module {896-985}
MOTIF: N-glycosylation site {N944}
fibronectin type III domain or F3 module {990-1088}
MOTIF: N-glycosylation site {N1038}
N-glycosylation site {N1080}
fibronectin type III domain or F3 module {1095-1187}
MOTIF: N-glycosylation site {N1101}
active site
fibronectin type III domain or F3 module {1192-1279}
fibronectin type III domain or F3 module {1284-1377}
MOTIF: N-glycosylation site {N1290}
N-glycosylation site {N1295}
fibronectin type III domain or F3 module {1382-1466}
fibronectin type III domain or F3 module {1472-1575}
fibronectin type III domain or F3 module {1580-1678}
fibronectin type III domain or F3 module {1683-1782}
N-glycosylation site {N1844}
transmembrane domain {1948-1968}
Tyrosine-protein phosphatase {2036-2292}
MOTIF: cysteine residue {C2233}
Database Correlations
OMIM 603317
UniProt Q9UMZ3
Pfam PF00102
ENZYME 3.1.3.48-
References
UniProt :accession Q9UMZ3