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phosphoribosylformylglycinamidine synthase; FGAM synthase; FGAMS; formylglycinamide ribotide amidotransferase; FGARAT; formylglycinamide ribotide synthetase (PFAS, KIAA0361)
Function:
- purine metabolism; IMP biosynthesis via de novo pathway 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N1-(5-phospho-D-ribosyl)glycinamide: step 1/2
ATP + N(2)-formyl-N1-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O
ADP + phosphate + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine + L-glutamate
Structure:
- in the N-terminal section; belongs to the FGAMS family
- contains 1 glutamine amidotransferase type-1 domain
Compartment: cytoplasm (putative)
Related
ornithine decarboxylase 1
General
amidotransferase
ligase or synthetase
phosphoprotein
Properties
SIZE: entity length = 1338 aa
MW = 145 kD
COMPARTMENT: cytoplasm
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 322-333
Ser phosphorylation site {S569}
Thr phosphorylation site {T619}
Thr phosphorylation site {T623}
Glutamine amidotransferase type-1 {1064-1302}
MOTIF: cysteine residue {C1158}
Database Correlations
OMIM 602133
UniProt O15067
PFAM correlations
ENZYME 6.3.5.3
References
UniProt :accession O15067