phosphopantothenate-cysteine ligase (phosphopantothenoylcysteine synthetase, PPC synthetase, PPCS, COAB)

Function: 1) catalyzes the first step in the biosynthesis of coenzyme A from vitamin B5 - conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine 2) mammalian enzyme has a preference for ATP over CTP, in contrast to the E. coli ortholog CTP + (R)-4'-phosphopantothenate + L-cysteine CMP + PPi + N-((R)-4'-phosphopantothenoyl)-L-cysteine Structure: homodimer

Properties

SIZE: MW = 34 kD entity length = 311 aa MOTIF: active site

Database Correlations

UniProt Q9HAB8 Pfam PF04127 ENZYME 6.3.2.5

References

UniProt :accession Q9HAB8