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phospholipid transfer protein; lipid transfer protein II (PLTP)
Function:
- converts HDL into larger & smaller particles
- may play a key role in extracellular phospholipid transport & modulation of HDL particles
Structure:
- belongs to the BPI/LBP/plunc superfamily, BPI/LBP family
Compartment: secreted
Alternative splicing: named isoforms=2
Expression:
- wide tissue distribution
- expressed in placenta > pancreas > lung > kidney > heart > liver > skeletal muscle > brain
Specific
non-specific phospholipid transfer protein
phosphatidylcholine transfer protein; PC-TP; START domain-containing protein 2; StARD2; StAR-related lipid transfer protein 2 (PCTP, STARD2)
phosphatidylcholine/phosphatidylinositol transfer protein
General
lipid transfer protein
phosphoprotein
secreted protein
Properties
SIZE: entity length = 493 aa
MW = 55 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-17}
N-glycosylation site {N64}
Thr phosphorylation site {T93}
N-glycosylation site {N94}
Ser phosphorylation site {S96}
N-glycosylation site {N117}
N-glycosylation site {N143}
cysteine residue {C146}
MODIFICATION: cysteine residue {C185}
cysteine residue {C185}
MODIFICATION: cysteine residue {C146}
N-glycosylation site {N245}
N-glycosylation site {N398}
Database Correlations
OMIM 172425
MORBIDMAP 172425
UniProt P55058
PFAM correlations
Entrez Gene 5360
Kegg hsa:5360
References
- UniProt :accession P55058
- SeattleSNPs
http://pga.gs.washington.edu/data/pltp/
- Rothman Nature 'News & Views' 347:519 1990