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phospholipase D3 (PLD 3, choline phosphatase 3, phosphatidylcholine-hydrolyzing phospholipase D3, HindIII K4L homolog, Hu-K4, PLD3)
Function:
phosphatidylcholine + H2O choline + phosphatidate
Structure:
- glycosylated
- belongs to the phospholipase D family
- contains 2 PLD phosphodiesterase domains
Compartment: endoplasmic reticulum membrane
Expression:
- widely expressed
- expressed at higher level in brain
- expressed at low level in corpus callosum, suggesting that it is highly expressed in neurons
Pathology:
- rare polymorphism in PLD3 increases risk for late-onset Alzheimer's disease [2]
General
glycoprotein
membrane protein
phospholipase-D (PLD)
Properties
SIZE: MW = 55 kD
entity length = 490 aa
COMPARTMENT: endoplasmic reticulum
MOTIF: transmembrane domain {39-59}
N-glycosylation site {N132}
PLD phosphodiesterase 1 {196-223}
MOTIF: histidine residue {H201}
lysine residue {K203}
aspartate residue {D208}
PLD phosphodiesterase 2 {411-437}
STATE: active state
Database Correlations
UniProt Q8IV08
PFAM correlations
Kegg hsa:2364
ENZYME 3.1.4.4
References
- UniProt :accession Q8IV08
- Cruchaga C et al.
Rare coding variants in the phospholipase D3 gene confer risk
for Alzheimer's disease.
Nature 2013 Dec 11
PMID: 24336208