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phospholipase-D (PLD)
Function:
- hydrolyzes phosphatidylcholine to phosphatadic acid + choline
- may be activated by ceramide [3]
Interactions
molecular events
Related
ceramide
Specific
inactive phospholipase D5 (inactive PLD 5, inactive choline phosphatase 5, inactive phosphatidylcholine-hydrolyzing phospholipase D5, PLDc, PLD5)
N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D (NAPE-hydrolyzing phospholipase D, NAPE-PLD, NAPEPLD, C7orf18)
phosphatidylinositol [PI] glycan-specific phospholipase D1 (glycoprotein phospholipase D1, glycosyl-phosphatidylinositol specific phospholipase D1, GPLD1, PIGPLD1)
phosphatidylinositol [PI] glycan-specific phospholipase D2 (glycoprotein phospholipase D2, glycosyl-phosphatidylinositol specific phospholipase D2, GPLD2)
phospholipase D family member FLJ33580 (PLD6)
phospholipase D3 (PLD 3, choline phosphatase 3, phosphatidylcholine-hydrolyzing phospholipase D3, HindIII K4L homolog, Hu-K4, PLD3)
phospholipase D4 (PLD 4, choline phosphatase 4, phosphatidylcholine-hydrolyzing phospholipase D4, PLD4, C14orf175, UNQ2488/PRO5775)
phospholipase-D1 (PLD1, choline phosphatase 1, phosphatidylcholine-hydrolyzing phospholipase D1, hPLD1)
phospholipase-D2, choline phosphatase 2 (phosphatidylcholine-hydrolyzing phospholipase D2, hPLD2, PLD1C, PLD2)
General
Ca+2 binding protein
guanine nucleotide regulatory protein [GNRP] effector
phospholipase
Properties
MOTIF: binding site
FOR-BINDING-OF: G-alpha
Ca+2-binding site
EFFECTOR-BOUND: Ca+2
STATE: active state
References
- Dennis EA, Rhee SG, Billah MM, Hannun YA.
Role of phospholipase in generating lipid second messengers
in signal transduction.
FASEB J. 1991 Apr;5(7):2068-77. Review.
PMID: 1901288
- Liscovitch M.
Crosstalk among multiple signal-activated phospholipases.
Trends Biochem Sci. 1992 Oct;17(10):393-9. Review.
PMID: 1455508
- Hannun YA, Obeid LM.
Ceramide: an intracellular signal for apoptosis.
Trends Biochem Sci. 1995 Feb;20(2):73-7. Review.
PMID: 7701566
- Wikipedia, hospholipase D entry
http://en.wikipedia.org/wiki/phospholipase_D