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phospholipase A2 group 7; platelet-activating factor acetylhydrolase; PAF acetylhydrolase; PAF 2-acylhydrolase; LDL-associated phospholipase A2; LDL-PLA2; lipoprotein-associated phospholipase A2; 2-acetyl-1-alkylglycerophosphocholine esterase; 1-alkyl-2-acetylglycerophosphocholine esterase (PAFAH, PLA2G7)

Function: - modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF - has a specificity for substrates with a short residue at the sn-2 position - inactive against long-chain phospholipids 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate Structure: - belongs to the AB hydrolase superfamily, lipase family Compartment: secreted, extracellular space Expression: - the source of plasma PAF acetylhydrolase is not known, but cultured macrophages secrete large amounts & hepatocytes secrete less Polymorphism: - the alleles Thr-198 & Val-379 are associated with atopy & asthma Pathology: - defects in PLA2G7 are the cause of platelet-activating factor acetylhydrolase deficiency - marker for vascular inflammation [4] Comparative biology: - there is apparently an intracellular enzyme of bovine brain that shares no sequence similarity outside the region of the active site

Related

lipoprotein-associated phospholipase A2 (Lp-PLA2) in serum/plasma

General

glycoprotein phospholipase A2; phosphatidylcholine 2-acylhydrolase (PLA2) secreted protein

Properties

SIZE: MW = 50 kD entity length = 441 aa COMPARTMENT: extracellular compartment MOTIF: active site MOTIF: serine residue {S273} aspartate residue {D296} histidine residue {H351} N-glycosylation site {N423} N-glycosylation site {N433}

Database Correlations

OMIM 601690 MORBIDMAP 601690 UniProt Q13093 Pfam PF03403 Entrez Gene 7941 Kegg hsa:7941 ENZYME 3.1.1.4.7

References

  1. Tjoelker LW et al Anti-inflammatory properties of a platelet-activating factor acetylhydrolase. Nature 374:549 1995 PMID: 7700381
  2. UniProt :accession Q13093
  3. SeattleSNPs http://pga.gs.washington.edu/data/pla2g7/
  4. Young K, Fairchild DG, Di Francesco L FDA Clears Test to Help Predict Coronary Heart Disease Risk Physician's First Watch, Dec 17, 2014 David G. Fairchild, MD, MPH, Editor-in-Chief Massachusetts Medical Society http://www.jwatch.org - FDA News Release. December 15, 2014 FDA clears test that helps predict the risk of coronary heart disease. Study data show test predicts risk better in black women. http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm426799.htm