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phosphoinositide-5-kinase

Function: - PIP-5-kinase is a lipid kinase specific to PI-4-phosphate, yielding PI-4,5-bisphosphate (PIP2), the preferred substrate of phospholipase C (PLC) - PIP-5-kinase is activated in vitro by rho.

Interactions

molecular events

Specific

FYVE finger-containing phosphoinositide kinase; 1-phosphatidylinositol-4-phosphate 5-kinase; PtdIns(4)P-5-kinase p235 (PIP5K, PIKFYVE) phosphatidylinositol-4-phosphate 5-kinase type 2 alpha; phosphoinositide-5-kinase 3; PIP5KII-alpha; 1-phosphatidylinositol-4-phosphate 5-kinase 2-alpha; PtdIns(4)P-5-kinase B isoform; diphosphoinositide kinase 2-alpha (PIP5K2A, PIP5K2, PIP4K2A) phosphatidylinositol-4-phosphate 5-kinase type-1 alpha; PIP5K1-alpha; Ptdins(4)P-5-kinase 1 alpha; 68 kD type 1 phosphatidylinositol-4-phosphate 5-kinase alpha; phosphatidylinositol-4-phosphate 5-kinase type 1 alpha; PIP5KIalpha (PIP5K1A) phosphatidylinositol-4-phosphate 5-kinase type-1 beta; PIP5K1-beta; Ptdins(4)P-5-kinase 1 beta; phosphatidylinositol-4-phosphate 5-kinase type I beta; PIP5KIbeta; protein STM-7; type I phosphatidylinositol-4-phosphate 5-kinase beta (PIP5K1B STM7) phosphatidylinositol-4-phosphate 5-kinase type-1 gamma; PIP5K1-gamma; Ptdins(4)P-5-kinase 1 gamma; phosphatidylinositol-4-phosphate 5-kinase type I gamma; PIP5KIgamma (PIP5K1C, KIAA0589) phosphatidylinositol-4-phosphate 5-kinase type-2 gamma; PI(4)P 5-kinase type 2 gamma; PIP5K2-gamma (PIP5K2C, PIP4K2C) Phosphatidylinositol-4-phosphate 5-kinase-like protein 1 (PtdIns(4)P-5-kinase-like protein 1, PI(4)P 5-kinase-like protein 1, PIP5KL1) phosphatidylinositol-5-phosphate 4-kinase type-2 beta; 1-phosphatidylinositol-5-phosphate 4-kinase 2-beta; diphosphoinositide kinase 2-beta; phosphatidylinositol-5-phosphate 4-kinase type 2 beta; PI(5)P 4-kinase type 2 beta; PIP4KII-beta; Ptdins(5)P-4-kinase isoform 2-beta (PIP4K2B, PIP5K2B)

General

kinase or ATP-phosphotransferase phosphoprotein regulatory molecule

Properties

STATE: active state MOTIF: kinase domain MOTIF: ATP-binding site NAME: ATP-binding site phosphorylation site

References

  1. Clark EA & Brugge JS Integrins and signal transduction pathways: the road taken. Science 268:233 1995 PMID: 7716514
  2. Nolan RD, Lapetina EG. Thrombin stimulates the production of a novel polyphosphoinositide in human platelets. J Biol Chem. 1990 Feb 15;265(5):2441-5. PMID: 2154447
  3. Alberts et al Molecular Biology of the Cell, 2nd ed. 1989, pg 702

Component-of

molecular complex