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phosphoinositide 3-kinase regulatory subunit 4 (PI3-kinase regulatory subunit 4, PI3-kinase p150 subunit, phosphoinositide 3-kinase adaptor protein, PIK3R4)
Function:
- regulatory subunit of the PI3K complex
- regulation of membrane trafficking late in the endocytic pathway
- associates with the phosphatidylinositol 3-kinase type 3
- probably autophosphorylated
General
kinase or ATP-phosphotransferase
myristoylated protein
protein subunit
WD repeat protein family
Properties
SIZE: MW = 153 kD
entity length = 1357 aa
MOTIF: myristoylation site
SITE: N-TERMINUS
kinase domain
SITE: 25-323
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 31-39
ATP-binding site
NAME: ATP-binding site
SITE: 52-52
aspartate residue {D147}
HEAT repeat {412-449}
HEAT repeat {457-494}
HEAT repeat {571-609}
glutamate-rich region {780-783}
MOTIF: glutamate residue (SEVERAL)
proline-rich region
SITE: 973-976
MOTIF: proline residue (SEVERAL)
WD repeat {990-1029}
WD repeat {1039-1078}
WD repeat {1092-1133}
WD repeat {1138-1177}
WD repeat {1181-1222}
WD repeat {1236-1277}
WD repeat {1326-1357}
Database Correlations
OMIM 602610
UniProt Q99570
PFAM correlations
References
UniProt :accession Q99570