Search
phosphohexose isomerase (PHI, phosphoglucose isomerase, PGI, phosphofructose isomerase, neuroleukin, NLK)
Function:
- catalyzes conversion of glucose-6-phosphate to fructose-6-phosphate
- neuroleukin is a neurotrophic factor for spinal & sensory neurons
- carbohydrate degradation; glycolysis
- D-glyceraldehyde 3- phosphate & glycerone phosphate from D-glucose, step 2/4
D-glucose 6-phosphate D-fructose 6- phosphate
Structure:
- homodimer
- belongs to the GPI family
Compartment: cytoplasm
Pathology:
- defects in GPI are a cause of hereditary nonspherocytic hemolytic anemia
Interactions
molecular events
Related
gluconeogenesis
glycolytic pathway (glycolysis, Embden Myerhof pathway)
General
glycolytic enzyme
isomerase
Properties
COMPARTMENT: cytoplasm
MOTIF: active site
Database Correlations
OMIM 172400
MORBIDMAP 172400
UniProt P06744
ENZYME 5.3.1.9
References
- UniProt :accession P06744
- SHMPD; The Singapore human mutation & polymorphism database
http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=GPI
- Wikipedia; phosphoglucose isomerase entry
http://en.wikipedia.org/wiki/phosphoglucose_isomerase