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phosphatidylserine-prothrombin complex
Structure:
- subunits include:
- phosphatidylserine
- prothrombin
Laboratory:
- phosphatidylserine-prothrombin complex IgG in serum/plasma
- phosphatidylserine-prothrombin complex IgM in serum/plasma
Related
phosphatidylserine
prothrombin; coagulation factor II; contains: activation peptide fragment 1; activation peptide fragment 2; thrombin light chain; thrombin heavy chain (F2)
General
molecular complex
Properties
SUBUNITS: phosphatidylserine
prothrombin
MOTIF: signal sequence {1-24}
Gla {44-89}
MOTIF: cysteine residue {C60}
MODIFICATION: cysteine residue {C65}
cysteine residue {C65}
MODIFICATION: cysteine residue {C60}
cysteine residue {C90}
MODIFICATION: cysteine residue {C103}
cysteine residue {C103}
MODIFICATION: cysteine residue {C90}
Kringle 1 {108-186}
MOTIF: cysteine residue {C108}
MODIFICATION: cysteine residue {C186}
N-glycosylation site {N121}
cysteine residue {C129}
MODIFICATION: cysteine residue {C169}
N-glycosylation site {N143}
cysteine residue {C157}
MODIFICATION: cysteine residue {C181}
cysteine residue {C169}
MODIFICATION: cysteine residue {C129}
cysteine residue {C181}
MODIFICATION: cysteine residue {C157}
cysteine residue {C186}
MODIFICATION: cysteine residue {C108}
proteolytic site {198-199}
Kringle 2 {213-291}
MOTIF: cysteine residue {C213}
MODIFICATION: cysteine residue {C291}
cysteine residue {C234}
MODIFICATION: cysteine residue {C274}
cysteine residue {C262}
MODIFICATION: cysteine residue {C286}
cysteine residue {C274}
MODIFICATION: cysteine residue {C234}
cysteine residue {C286}
MODIFICATION: cysteine residue {C262}
cysteine residue {C291}
MODIFICATION: cysteine residue {C213}
proteolytic site {327-328}
cysteine residue {C336}
MODIFICATION: cysteine residue {C-INTERCHAIN}
proteolytic site {363-364}
S1 domain {364-618}
MOTIF: cysteine residue {C391}
MODIFICATION: cysteine residue {C407}
histidine residue {H406}
cysteine residue {C407}
MODIFICATION: cysteine residue {C391}
N-glycosylation site {N416}
aspartate residue {D462}
cysteine residue {C536}
MODIFICATION: cysteine residue {C550}
cysteine residue {C550}
MODIFICATION: cysteine residue {C536}
binding site
SITE: 551-573
FOR-BINDING-OF: HIGH motif
cysteine residue {C564}
MODIFICATION: cysteine residue {C594}
serine residue {S568}
cysteine residue {C594}
MODIFICATION: cysteine residue {C564}
PRECURSOR-FOR: thrombin
COMPARTMENT: plasma
STATE: active state
References
Loinc
Components
phosphatidylserine
prothrombin; coagulation factor II; contains: activation peptide fragment 1; activation peptide fragment 2; thrombin light chain; thrombin heavy chain (F2)