GPI transamidase component PIG-T; phosphatidylinositol-glycan biosynthesis class T protein (PIGT)

Function: - component of the GPI transamidase complex - essential for transfer of GPI to proteins, particularly for formation of carbonyl intermediates - glycolipid biosynthesis; GPI-anchor biosynthesis - the disulfide bond between PIGK/GPI8 & PIGT is important for normal enzyme activity - forms a complex with PIGK/GPI8, PIGS, PIGU & GPAA1/GAA1 - role in maintaining the complex by stabilizing expression of GPAA1 & GPI8 & linking them to PIGS Structure: belongs to the PIGT family Compartment: - endoplasmic reticulum membrane - single-pass type 1 membrane protein Alternative splicing: named isoforms=4

General

glycoprotein membrane protein phosphatidylinositol-glycan biosynthesis protein (PIG-protein)

Properties

SIZE: entity length = 578 aa MW = 66 kD COMPARTMENT: endoplasmic reticulum MOTIF: signal sequence {1-21} N-glycosylation site {N164} cysteine residue {C182} MODIFICATION: cysteine residue {C92 IN PIGK/GPI8} N-glycosylation site {N291} N-glycosylation site {N327} transmembrane domain {528-548}

Database Correlations

OMIM 610272 UniProt Q969N2 Pfam PF04113 Entrez Gene 51604 Kegg hsa:51604

References

UniProt :accession Q969N2