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GPI ethanolamine phosphate transferase 3; phosphatidylinositol-glycan biosynthesis class O protein; PIG-O (PIGO)
Function:
- ethanolamine phosphate transferase involved in GPI-anchor biosynthesis
- transfers ethanolamine phosphate to the GPI third mannose which links the GPI-anchor to the C-terminus of the proteins by an amide bond
- glycolipid biosynthesis; GPI-anchor biosynthesis
- forms a complex with PIGF
- PIGF is required to stabilize PIGO (putative)
Structure:
- belongs to the PIGG/PIGN/PIGO family, PIGO subfamily
Compartment:
- endoplasmic reticulum membrane
- multi-pass membrane protein (putative)
Alternative splicing:
- named isoforms=2
- additional isoforms seem to exist
Related
phosphatidylinositol [PI] glycan
General
glycoprotein
phosphatidylinositol-glycan biosynthesis protein (PIG-protein)
transmembrane 14 protein
Properties
SIZE: entity length = 1089 aa
MW = 119 kD
COMPARTMENT: endoplasmic reticulum
MOTIF: transmembrane domain {4-24}
N-glycosylation site {N268}
transmembrane domain {457-477}
transmembrane domain {482-502}
transmembrane domain {510-530}
transmembrane domain {541-561}
transmembrane domain {575-595}
transmembrane domain {668-688}
transmembrane domain {701-721}
transmembrane domain {747-767}
transmembrane domain {830-850}
transmembrane domain {857-877}
transmembrane domain {944-964}
transmembrane domain {1014-1034}
transmembrane domain {1048-1068}
Database Correlations
UniProt Q8TEQ8
Pfam PF01663
Entrez Gene 84720
Kegg hsa:84720
References
UniProt :accession Q8TEQ8