phosphatidylinositol 4-kinase type 2-beta

Function: - together with PI4K2A & the type 3 PI4Ks (PIK4CA & PIK4CB), contributes to the overall PI4-kinase activity of cell - especially significant in plasma membrane, endosomal & Golgi compartments - phosphorylation of phosphatidylinositol (PI) to PI4P is the 1st committed step in the generation of PIP2, a precursor of the second messenger inositol 1,4,5-trisphosphate (IP3) - contributes to the production of IP3 in stimulated cells - role in the regulation of vesicular trafficking ATP + 1-phosphatidyl-1D-myo-inositol ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate Structure: - belongs to the PI3/PI4-kinase family, type II PI4K subfamily - contains 1 PI3K/PI4K domain Compartment: - cytoplasm, membrane - recruited & activated by membrane association - binding to the microsomal membrane enhances activity - mostly cytoplasmic - also found associated with plasma membrane, Golgi & endosomes - compared to PI4K2A, a larger fraction of PI4K2B is cytosolic due to a smaller extent of palmitoylation - translocates to membranes where it is recruited by PDGF stimulation by a Rac-GTP-dependent mechanism Expression: widely expressed

Properties

SIZE: MW = 55 kD entity length = 481 aa COMPARTMENT: cytoplasm golgi MOTIF: glutamate-rich region {19-22} MOTIF: glutamate residue (SEVERAL) PI3K/PI4K {129-436}

Database Correlations

UniProt Q8TCG2 Pfam PF00454 ENZYME 2.7.1.67

References

UniProt :accession Q8TCG2