phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein; P-Rex1; Ptdins(3,4,5)-dependent Rac exchanger 1 (PREX1, KIAA1415)

Function: - RAC guanine nucleotide exchange factor (GEF), which activates Rac proteins by exchanging bound GDP for free GTP - synergistically activated by PI-3,4,5-triphosphate & G-beta-gamma - may function downstream of heterotrimeric G proteins in neutrophils - interacts preferentially with RAC2 (putative) - interacts with RAC1 Structure: - contains 1 DEP domain - contains 1 DH (DBL-homology) domain - contains 1 PDZ domain (DHR domain) - contains 2 PH domains Compartment: - cytoplasm, cell membrane - mainly cytosolic - some amount is associated with the plasma membrane Alternative splicing: named isoforms=3 Expression: - mainly expressed in peripheral blood leukocytes & brain - expressed at intermediate level in spleen & lymph nodes - weakly expressed in other tissues

General

guanine nucleotide exchange factor (GDP/GTP dissociation stimulator, guanine nucleotide-releasing factor/protein, GNEF, GNDS, GDS) human longevity protein phosphoprotein

Properties

SIZE: entity length = 1659 aa MW = 186 kD COMPARTMENT: cytoplasm MOTIF: Dbl homology domain {49-240} PH domain {271-392} DEP domain {421-496} MOTIF: Ser phosphorylation site {S436} DEP domain {523-597} PDZ domain NAME: PDZ domain SITE: 625-703

Database Correlations

OMIM 606905 UniProt Q8TCU6 PFAM correlations Entrez Gene 57580 Kegg hsa:57580

References

UniProt :accession Q8TCU6