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phosphatidylcholine (lecithin)
Component of lipoproteins.
Pathology:
- gut bacteria convert dietary phosphatidylcholine (lecithin) to trimethylamine-N-oxide that is absorbed & appears in plasma
- increased plasma trimethylamine-N-oxide is associated with increased cardiovascular risk [2]
- oxidized choline glycerophospholipids activate platelet CD36, promote platelet activation, impair endothelial function & increase foam cell concentration within atherosclerotic plaques [1]
Interactions
molecular events
Related
phosphatidylcholine antibody in serum
Specific
dipalmitoyllecithin; dipalmitoylphosphatidyl choline
lysophosphatidylcholine
soy lecithin
soybean lecithin
General
bioagent
glyceride
phospholipid
Properties
COMPARTMENT: cellular membrane
Database Correlations
PUBCHEM cid=168614
References
- Podrez EA, Byzova TV, Febbraio M, Salomon RG, Ma Y,
Valiyaveettil M, Poliakov E, Sun M, Finton PJ, Curtis BR,
Chen J, Zhang R, Silverstein RL, Hazen SL.
Platelet CD36 links hyperlipidemia, oxidant stress and a
prothrombotic phenotype.
Nat Med. 2007 Sep;13(9):1086-95. Epub 2007 Aug 26.
PMID: 17721545
- Jackson SP, Calkin AC.
The clot thickens-oxidized lipids and thrombosis.
Nat Med. 2007 Sep;13(9):1015-6.
PMID: 17828215
http://jama.ama-assn.org/cgi/content/full/297/5/499
- Tang WHW et al.
Intestinal microbial metabolism of phosphatidylcholine and
cardiovascular risk.
N Engl J Med 2013 Apr 25; 368:1575
PMID: 23614584
http://www.nejm.org/doi/full/10.1056/NEJMoa1109400
- Loscalzo J.
Gut microbiota, the genome, and diet in atherogenesis.
N Engl J Med 2013 Apr 25; 368:1647.
PMID: 23614591
http://www.nejm.org/doi/full/10.1056/NEJMe1302154
Component-of
cider vinegar/kelp/phosphatidylcholine/pyridoxine
garlic/phosphatidylcholine
oxidized low density lipoprotein (oxidized LDL, oxLDL)