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phosphate carrier (phosphate transporter/translocase, PTP, solute carrier family 25 member 3, SLC25A3, PHC, OK/SW-cl48)
Function:
- transport of phosphate groups from the cytosol to the mitochondrial matrix
- phosphate is cotransported with H+
Structure:
- belongs to the mitochondrial carrier family
- contains 3 solcar repeats
Compartment:
- mitochondrial inner membrane
Alternative splicing: named isoforms=2
Pathology:
- defects in SLC25A3 are a cause of mitochondrial phosphate carrier deficiency
General
mitochondrial membrane protein
permease
solute carrier family 25 (SLC25, SLC25A)
Properties
COMPARTMENT: inner mitochondrial membrane
MOTIF: Solcar {63-147}
MOTIF: transmembrane domain {64-86}
transmembrane domain {122-141}
Solcar {160-244}
MOTIF: transmembrane domain {162-183}
transmembrane domain {219-238}
Solcar {261-339}
MOTIF: transmembrane domain {262-284}
transmembrane domain {315-333}
Database Correlations
OMIM 600370
MORBIDMAP 600370
UniProt Q00325
Pfam PF00153
Kegg hsa:5250
References
- Principles of Biochemistry 6th ed., White, Handler,
Smith, Hill, & Lehman (eds.) McGraw-Hill, NY 1978,
pg 345
- Molecular Cell Biology (2nd ed) Darnell J; Lodish H
& Baltimore D (eds), Scientific American Books,
WH Freeman, NY 1990, pg 602
- UniProt :accession Q00325