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phosphatase-1 (PP1)
Function:
- protein phosphatase 1 (PP1) is essential for cell division, & participates in the regulation of glycogen metabolism, muscle contractility & protein synthesis
- involved in regulation of ionic conductances & long-term synaptic plasticity
- may play a role in dephosphorylating substrates such as the postsynaptic density-associated CaM kinase 2
- exhibits broad specificity, partly overlapping with protein phosphatase 2A
Inhibition:
- inhibited by calyculin A [3] & akadaic acid
phosphoprotein + H2O = a protein + phosphate Struture:
- PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, which is folded into its native form by inhibitor 2 & glycogen synthetase kinase 3, & then complexed to one or several targeting or regulatory subunits
- PPP1R12A, PPP1R12B & PPP1R12C mediate binding to myosin
- PPP1R3A, PPP1R3B, PPP1R3C & PPP1R3D mediate binding to glycogen
- PPP1R15A & PPP1R15B mediate binding to EIF2S1
Compartment:
- cytoplasm, nucleus, nucleoplasm, nucleolus
- primarily nuclear & largely excluded from the nucleolus
- highly mobile in cells & can be relocalized through interaction with targeting subunits
Notes:
- related complexes
- PTW/PP1 phosphatase complex
- PPP1R15A-PP1 complex
Interactions
molecular events
Related
PPP1R15A-PP1 complex
PTW/PP1 phosphatase complex
Specific
protein phosphatase 1J; protein phosphatase 2C isoform zeta; PP2C-zeta (PPM1J, PPP2CZ)
General
multisubunit protein
nuclear protein
phosphoprotein
serine/threonine phosphatase
Properties
COMPARTMENT: cell nucleus
STATE: active state
SUBUNITS: phosphatase-1 catalytic subunit
MOTIF: phosphorylation site
STATE: active state
protein phosphatase-1 regulatory subunit
INHIBITS: phosphatase
MOTIF: S/T-phosphate
allosteric site
MISC-INFO: INHIBITOR = OKADAIC_ACID
INHIBITOR = HISTONE_H1
References
- UniProt :accession P62136
- Armstrong DL
Calcium channel regulation by calcineurin, a Ca2+-activated
phosphatase in mammalian brain.
TINS 12(3):117 1989
PMID: 2469218
- Denton RM.
Insulin signalling: search for the missing links.
Nature. 1990 Nov 22;348(6299):286-7.
PMID: 2250701
- Kosik KS, Shimura H.
Phosphorylated tau and the neurodegenerative foldopathies.
Biochim Biophys Acta. 2005 Jan 3;1739(2-3):298-310. Epub 2004
Nov 26. Review.
PMID: 15615647
Component-of
molecular complex
Components
phosphatase-1 catalytic subunit
protein phosphatase-1 regulatory subunit