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DNA dC->dU-editing enzyme APOBEC-3A; phorbolin-1 (APOBEC3A)
Function:
- single-stranded DNA cytidine deaminase involved in foreign DNA clearance
- may trigger C-to-U hypermutation in exogenous DNA leading to its degradation
- provides cellular innate resistance to a specific panel of genetic invaders including endogenous retroelements & a subset of viruses
- may have a preference for cytidines in a C-C sequence context
- may also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation
cytidine + H2O = uridine + NH3
Cofactor: Zn+2 (putative)
Structure:
- belongs to the cytidine & deoxycytidylate deaminase family
Compartment:
- nucleus, cytoplasm
Alternative initiation: Named isoforms=2
Expression:
- expressed in peripheral blood leukocytes
- higher expression in CD14-positive phagocytic cells
- also detected in non-lymphoid tissues including lung & adipose tissues
- also detected in keratinocytes
- up-regulated by interferon & CpG single-stranded DNA (at protein level)
Notes:
- one of 7 related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22
General
DNA dC->dU-editing enzyme (phorbolin)
nuclear protein
Properties
SIZE: entity length = 199 aa
MW = 23 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: Zn+2-binding site
SITE: 70-70
glutamate residue {E72}
Zn+2-binding site
SITE: 101-101
Zn+2-binding site
SITE: 106-106
Database Correlations
OMIM 607109
UniProt P31941
PFAM correlations
Entrez Gene 200315
Kegg hsa:200315
References
UniProt :accession P31941