phenytoin, topical (Dilantin)

Indications: 1) pressure ulcers 2) diabetic ulcers 3) burns 4) traumatic wounds Dosage: (application) 1) apply a thin layer of phenytoin powder USP directly to wound QD & cover with a sterile bandage 2) mix the contents of a 100 mg phenytoin capsule with 5 mL of sterile saline; soak gauze in it & place over the wound change dressing daily Pharmacokinetics: -> very little absorbed Mechanism of action: 1) promotes wound healing 2) enhances synthesis of collagen 3) promotes growth of fibroblasts 4) related to effects on gingival hyperplasia

Interactions

drug adverse effects of anticonvulsants monitor with anticonvulsants

General

phenytoin; diphenylhydantoin; PTN (Dilantin, Dephenylan, Antilepsin) topical agent

References

Prescriber's Letter 8(8): 45, 2001