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phentermine (Fastin, Ionamin, Adipex)
Tradenames: Fastin, Ionamin. DEA-controlled substance: class 4.
Indications:
- short-term treatment for weight reduction
Contraindications:
- glaucoma
- hypertension
- hyperthydoidism
- coronary artery disease
- heart failure
- agitation
- pregnancy
- lactation
Dosage:
1) start 15-30 mg PO QD
2) maximum: 37.5 mg QD
Tabs: 8, 15, 18.75, 30 mg.
Pharmacokinetics:
1) metabolized in liver to largely inactive metabolites
2) metabolites excreted by the kidney
3) 1/2life: 7-24 hours
Adverse effects:
1) insomnia
2) agitation
3) nervousness
4) hyperthermia
5) hyperventilation
6) hypertension
7) convulsions
Drug interactions:
- may cause false positives in immunoassays for amphetamines in urine
Mechanism of action:
1) CNS stimulants
2) appetite suppressant
Interactions
drug adverse effects (more general classes)
Related
chlorphentermine (Clorfentermina, Desopimon, Dezopimon, Lucofene)
mephentermine (Wyamine)
General
adrenergic neuron stimulant
amine
analeptic (CNS stimulant)
anorexiant (appetite suppressant)
aromatic compound
Properties
MISC-INFO: elimination route KIDNEY
LIVER
therapeutic-range 30-90 NG/ML
1/2life 7-24 HOURS
toxic-range >5 UG/ML
pregnancy-category ?
safety in lactation ?
Database Correlations
PUBCHEM correlations
References
- The Pharmacological Basis of Therapeutics, 9th ed.
Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed.,
W.B. Saunders, 1995
- Micromedex
- Harrison's Principles of Internal Medicine, 14th ed.
Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 461
Component-of
fenfluramine/phentermine (fen-phen)
phentermine/topiramate (Qnexa, Qsymia)