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phensuximide (Milontin)
Tradename: Milontin.
Indications: seizures
Dosage: 500-1000 mg PO BID/TID
Tabs: 500 mg
Pharmacokinetics:
1) rapidly absorbed
2) metabolized in liver to active N-desmethyl derivative
Adverse effects:
1) nausea/vomiting
2) anorexia
3) headache
4) fatigue
5) lethargy
6) dizziness
Drug interactions:
1) agents which increase phensuximide metabolism
a) carbamazepine
b) phenobarbital
c) phenytoin
d) primidone
2) valproic acid may increase or decrease phensuximide concentration
Laboratory:
1) specimen: serum, plasma (heparin, EDTA)
2) methods: GLC, HPLC
Interactions
drug interactions
drug adverse effects of anticonvulsants
monitor with anticonvulsants
General
anticonvulsant
succinimide
Properties
COMPARTMENT: mitochondrial matrix
MISC-INFO: elimination route LIVER
KIDNEY
1/2life 4 HOURS
therapeutic-range 40-60 UG/ML
protein-binding <5%
elimination by hemodialysis -
hemoperfusion -
peritoneal dialysis -
pregnancy-category C
safety in lactation ?
Database Correlations
PUBCHEM cid=6839
References
- The Pharmacological Basis of Therapeutics, 8th ed.
Gilman et al, eds. Permagon Press/McGraw Hill pg 450
- Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed.,
W.B. Saunders, 1995