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phenmetrazine (Oxazimedrine, Preludin, Mefolin)
Pharmacokinetics:
1) metabolized in liver to largely inactive metabolites
2) metabolites excreted by the kidney
Adverse effects:
1) insomnia
2) agitation
3) nervousness
4) hyperthermia
5) hyperventilation
6) hypertension
7) convulsions
Interferences:
-> may cause false positives in immunoassays for amphetamines in urine
Mechanism of action:
1) CNS stimulant
2) appetite suppressant
Interactions
drug adverse effects (more general classes)
General
adrenergic neuron stimulant
amine
analeptic (CNS stimulant)
aromatic compound
Properties
MISC-INFO: elimination route LIVER
KIDNEY
1/2life 8 HOURS
therapeutic-range 60-250 NG/ML
toxic-range >5 UG/ML
Database Correlations
PUBCHEM correlations
References
Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed.,
W.B. Saunders, 1995