phenacetin (Acetophenetidin)

Non-narcotic analgesic removed from over the counter remedies in USA because of adverse effects: Pharmacokinetics: -> metabolized to acetaminophen Adverse effects: 1) nephrotoxicity (including capillary necrosis) 2) hemolysis 3) thrombocytopenia 4) methemoglobinemia Laboratory: 1) specimen: plasma (EDTA) 2) methods: GLC, HPLC, color, GC-MS 3) interferences: a) theophylline interferes with some HPLC procedures b) silyl derivatives for GLC are unstable c) colorimetric assays are non-specific

Properties

MISC-INFO: elimination route LIVER 1/2life 0.6 HOURS therapeutic-range 1-30 UG/ML toxic-range 50-250 UG/ML protein-binding 39%

References

Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed., W.B. Saunders, 1995