PHD finger protein 21A (BRAF35-HDAC complex protein BHC80, BHC80a, PHF21A, BHC80, KIAA1696, BM-006)

Function: - component of the BHC complex - in the complex, it interacts directly with HDAC1, HDAC2, HMG20B/BRAF35, AOF2/LSD1 & RCOR1/CoREST Structure: - contains 1 A.T hook DNA-binding domain - contains 1 PHD-type zinc finger Compartment: nucleus Alternative splicing: named isoforms=3 Expression: - highly expressed in brain - expressed at much lower level in other tissues

General

nuclear protein protein subunit

Properties

SIZE: MW = 75 kD entity length = 680 aa COMPARTMENT: cell nucleus MOTIF: glutamine-rich region {4-108} MOTIF: glutamine residue (SEVERAL) A+T hook SITE: 425-437 silencer element SITE: 486-680 MOTIF: Zn finger PHD-type NAME: Zn finger PHD-type SITE: 488-535 EFFECTOR-BOUND: Zn+2 coiled coil {558-603}

Database Correlations

OMIM 608325 UniProt Q96BD5 PFAM correlations

References

UniProt :accession Q96BD5