PHD finger protein 20 (hepatocellular carcinoma-associated antigen 58, glioma-expressed antigen 2, transcription factor TZP, novel zinc finger protein, PHF20, C20orf104, GLEA2, HCA58, NZ,F TZP)

Function: transcription factor (putative) Structure: - contains 1 A.T hook DNA-binding domain - contains 1 C2H2-type zinc finger - contains 1 PHD-type zinc finger Compartment: nucleus Alternative splicing: named isoforms=2 Expression: - expressed in heart, kidney, liver, lung, pancreas, placenta, spleen, testis - not expressed in brain, skeletal muscle, colon, ovary, prostate, small intestine, thymus Pathology: - expressed in colon & ovarian cancer cell line, but not expressed in respective normal tissues - antibodies against PHF20 are present in sera from patients with hepatocellular carcinoma, glioblastoma* & childhood medulloblastula * may serve as diagnostic marker in glioblastoma

General

C2H2 type zinc finger protein transcription factor (TF)

Properties

SIZE: MW = 115 kD entity length = 1012 aa COMPARTMENT: cell nucleus MOTIF: lysine-rich region {162-221} MOTIF: lysine residue (SEVERAL) Ser phosphorylation site {S209} A+T hook SITE: 257-269 Zn finger C2H2-type SITE: 452-477 EFFECTOR-BOUND: Zn+2 lysine-rich region {523-552} MOTIF: lysine residue (SEVERAL) Zn finger PHD-type NAME: Zn finger PHD-type SITE: 654-700 EFFECTOR-BOUND: Zn+2

Database Correlations

UniProt Q9BVI0 PFAM correlations

References

UniProt :accession Q9BVI0