PHD finger protein 19 (polycomb-like protein 3, hPCL3, PHF19, PCL3)

Function: - acts as a transcritpional repressor - isoform 1 & isoform 2 inhibit transcription from an HSV-tk promoter Structure: contains 2 PHD-type Zn⁺² fingers Compartment: nucleus Alternative splicing: named isoforms=3 Expression: - isoform 1 is expressed in thymus, heart, lung & kidney - isoform 2 is predominantly expressed in placenta, skeletal muscle & kidney Pathology: - overexpressed in many types of cancers, including colon, skin, lung, rectal, cervical, uterus, liver cancers, in cell lines derived from different stages of melanoma & in glioma cell lines

General

nuclear protein zinc finger protein

Properties

SIZE: entity length = 580 aa MW = 66 kD COMPARTMENT: cell nucleus MOTIF: Zn finger PHD-type NAME: Zn finger PHD-type SITE: 96-151 EFFECTOR-BOUND: Zn+2 Zn finger PHD-type NAME: Zn finger PHD-type SITE: 195-249 EFFECTOR-BOUND: Zn+2

Database Correlations

UniProt Q5T6S3 Pfam PF00628 Kegg hsa:2614

References

UniProt :accession Q5T6S3