PHD finger protein 12; PHD factor 1; Pf1 (PHF12, KIAA1523)

Function: - transcriptional repressor - role in recruitment of functional SIN3A complexes to DNA. - represses transcription at least in part through the activity of an associated histone deacetylase - may also repress transcription in a SIN3A-independent manner through recruitment of functional AES complexes to DNA - isoform 2 interacts with SIN3A in a complex composed of HDAC1, SAP30 & SIN3A - interacts with AES Structure: - contains 1 FHA domain - contains 2 PHD-type zinc fingers Compartment: nucleus Alternative splicing: named isoforms=4 Expression:

General

phosphoprotein transcriptional silencer (transcriptional repressor) zinc finger protein

Properties

SIZE: MW = 110 kD entity length = 1004 aa COMPARTMENT: cell nucleus MOTIF: Zn finger PHD-type NAME: Zn finger PHD-type SITE: 56-105 EFFECTOR-BOUND: Zn+2 interaction with SIN3A {102-273} MOTIF: Ser phosphorylation site {S131} Zn finger PHD-type NAME: Zn finger PHD-type SITE: 271-321 EFFECTOR-BOUND: Zn+2 interaction with SIN3A {300-704} forkhead-associated (FHA) domain {815-869} Thr phosphorylation site {T880} arginine-rich region {894-897} MOTIF: arginine residue (SEVERAL) serine-rich region {929-932} MOTIF: serine residue (SEVERAL)

Database Correlations

UniProt Q96QT6 Pfam PF00628

References

UniProt :accession Q96QT6