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PHD finger protein 1; protein PHF1; polycomb-like protein 1; hPCl1 (PHF1, PCL1)
Function:
- transcriptional repressor
- may promote methylation of histone H3 on Lys-27 by the PRC2/EED-EZH2 complex
- interacts with CHMP1 (putative)
- interacts with the PRC2 complex
- phosphorylated on Ser-360
Structure: contains 2 PHD-type Zn+2 fingers
Compartment:
- nucleus. cytoplasm, cytoskeleton, centrosome
- localizes specifically to the promoters of numerous target genes
- colocalizes with NEK6 in the centrosome
Alternative splicing: named isoforms=2
Expression:
- highest expression in heart, skeletal muscle, & pancreas
- lower expression in brain, placenta, lung, liver & kidney
General
nuclear protein
PHD finger protein
phosphoprotein
Properties
SIZE: entity length = 567 aa
MW = 62 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: Zn finger PHD-type
NAME: Zn finger PHD-type
SITE: 87-142
EFFECTOR-BOUND: Zn+2
Zn finger PHD-type
NAME: Zn finger PHD-type
SITE: 186-240
EFFECTOR-BOUND: Zn+2
Ser phosphorylation site {S522}
Database Correlations
OMIM 602881
UniProt O43189
PFAM correlations
Entrez Gene 5252
Kegg hsa:5252
References
UniProt :accession O43189