phagocyte dysfunction

Etiology: 1) adherence-aggregation dysfunction a) drug-induced - aspirin - colchicine - alcohol - glucocorticoids - ibuprofen - piroxicam b) acquired - neonatal state - hemodialysis c) inherited - deficiency in leukocyte adhesion protein 2) deformability dysfunction (acquired) a) leukemia b) neonatal state c) diabetes mellitus d) immature neutrophils 3) chemokinesis-chemotaxis dysfunction a) drug-induced - glucocorticoids (high dose) - auranofin - colchicine (weak effect) - phenylbutazone - naproxen - indomethacin - interleukin-2 (IL-2) b) acquired - thermal injury - malignancy - malnutrition - periodontal disease - neonatal state - systemic lupus erythematosus - rheumatoid arthritis - diabetes mellitus - sepsis - influenza - Herpes simplex - acrodermatitis enteropathica - Down's syndrome - alpha-mannosidase deficiency - severe combined immunodeficiency - Wiskott-Aldrich syndrome - AIDS c) inherited - Chediak-Higashi syndrome - neutrophil-specific granule deficiency - Job's syndrome (some patient's) 4) microbicidal activity dysfunction a) drug-induced - colchicine - cyclophosphamide - glucocorticoids (high dose) b) acquired - leukemia - aplastic anemia - neutropenias (some) - tuftsin deficiency - thermal injury - sepsis - neonatal state - diabetes mellitus - malnutrition - AIDS c) inherited - Chediak-Higashi syndrome - neutrophil-specific granule deficiency - chronic granulomatous disease

References

Harrison's Principles of Internal Medicine, 13th ed. Isselbacher et al (eds), McGraw-Hill Inc. NY, 1994, pg 333