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PEST region
Motif common to most calpain sensitive proteins. Contains proline, glutamate, aspartate, serine & threonine residues. Site for serine/threonine kinase & Ca+2-binding.
Related
Ca+2
General
Ca+2-binding site
domain
Ser/Thr phosphorylation site
proteolytic site
References
- Choi JY et al
Molecular clonining and expression of a complementary DNA
for inositol 1,4,5-triphosphate 3-kinase
Science 248:64 1990
PMID: 2157285
- Wang KK et al
Calmodulin-binding proteins as calpain substrates.
Biochem J 262:693 1989
PMID: 2556106
- Rogers S et al,
Amino acids common to rapidly degraded proteins: The PEST
hypothesis
Science 234:364 1986
PMID: 2876518