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PEST protein
Interactions
molecular events
Specific
adenovirus oncoprotein E1a
alpha-actinin (ACTN)
b-myc proto-oncogene protein
band 3 anion transport protein; anion exchange protein 1; anion exchanger 1; AE 1; solute carrier family 4 member 1; CD233 (SLC4A1, AE1, DI, EPB3)
c-myc proto-oncogene protein; transcription factor p64 (c-Myc, MYC)
Ca+2 ATPase of plasma membrane; P-type ATPase subfamily IIB (PMCA)
calcineurin-binding protein cabin-1; calcineurin inhibitor; CAIN (CABIN1, KIAA0330)
calcium/calmodulin dependent protein kinase 2
calpain
calpastatin
cAMP-dependent protein kinase catalytic subunit or protein kinase A [PKA] catalytic subunit
casein
coagulation factor V; activated protein C cofactor; proaccelerin, labile factor; contains: coagulation factor V heavy chain; coagulation factor V light chain (F5)
connexin (gap-junction protein)
cyclin
epidermal growth factor receptor; receptor tyrosine-protein kinase ErbB-1 (EGFR, ERBB1, HER1)
estrogen receptor-1; estrogen receptor-alpha; ER; estradiol receptor; ER-alpha; nuclear receptor subfamily 3 group A member 1 (ESR1, ESR, NR3A1)
fibrinogen-alpha (FGA)
fibrinogen-alpha'
fibrinogen-beta (FGB)
fibrinogen-beta'
fibrinogen-gamma A (FGG)
fibrinogen-gamma B
fibrinogen-gamma'
fodrin (non erythrocytic spectrin)
heat shock protein [hsp] 70, HSP70A or HSP-A
induced myeloid leukemia cell differentiation protein Mcl-1; Bcl-2-related protein EAT/mcl1; mcl1/EAT; Bcl-2-like protein 3; Bcl2-L-3 (MCL1, BCL2L3)
inositol 1,4,5 triphosphate [IP3]-3-kinase
kininogen
L-myc proto-oncogene protein
microtubule-associated protein tau (neurofibrillary tangle protein, paired helical filament-tau, PHF-tau, MAPT, MTBT1, m-tau, mtau)
myosin light chain kinase (MLCK, MYLK)
neurofilament protein
neuromodulin; axonal membrane protein GAP-43; growth-associated protein 43; PP46; neural phosphoprotein B-50 (GAP43)
ornithine decarboxylase 1
Progesterone receptor; PR; nuclear receptor subfamily 3 group C member 3 (PGR, NR3C3)
protein kinase A [PKA] regulatory subunit
protein kinase A2 [PKA2] regulatory subunit; AKAP5; A-kinase anchor protein 79; AKAP-79 (PKA2R)
protein kinase C type-A
proto-oncogene protein c-Fos; cellular oncogene protein fos; G0/G1 switch regulatory protein 7 (FOS, G0S7)
pyruvate kinase L-type (pyruvate kinase R/L, PKLR)
spectrin
tubulin
vimentin (VIM)
von Willebrand factor; vWF; ristocetin cofactor; factor VIII related antigen; contains: von Willebrand antigen 2 (VWF, F8VWF)
General
Ca+2 binding protein
phosphoprotein
Properties
MOTIF: PEST region
References
- Rogers S et al,
Amino acids common to rapidly degraded proteins: The PEST
hypothesis
Science 234:364 1986
PMID: 2876518
- Choi JY et al
Molecular clonining and expression of a complementary DNA
for inositol 1,4,5-triphosphate 3-kinase
Science 248:64 1990
PMID: 2157285