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persephin; PSP (PSPN)
Function:
- neurotrophic activity on mesencephalic dopaminergic neurons & motor neurons
- homodimer; disulfide-linked (putative)
Structure:
- belongs to the TGF-beta family, GDNF subfamily
Compartment: secreted
General
growth factor
secreted protein
TGF-beta family protein
Properties
SIZE: entity length = 156 aa
MW = 17 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-21}
cysteine residue {C66}
MODIFICATION: cysteine residue {C124}
cysteine residue {C93}
MODIFICATION: cysteine residue {C152}
cysteine residue {C97}
MODIFICATION: cysteine residue {C154}
cysteine residue {C123}
MODIFICATION: cysteine residue {C-INTERCHAIN}
cysteine residue {C124}
MODIFICATION: cysteine residue {C66}
cysteine residue {C152}
MODIFICATION: cysteine residue {C93}
cysteine residue {C154}
MODIFICATION: cysteine residue {C97}
Database Correlations
OMIM 602921
UniProt O60542
Pfam PF00019
Entrez Gene 5623
Kegg hsa:5623
References
UniProt :accession O60542