peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PGC-1-related coactivator, PRC, PPRC1, KIAA0595)

Function: - coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis & cell growth - role in transcription coactivation of CREB & NRF1 target genes - interacts with CREB1 & NRF1 Structure: contains 1 RRM (RNA recognition motif) domain Compartment: - nucleus - colocalizes with NRF1 Alternative splicing: named isoforms=2 Expression: - expressed in heart & skeletal muscle > lung, placenta, intestine, liver, kidney, spleen, thymus, colon & brain - up-regulated by serum (at protein level) Pathology: - expressed in several oncocytic thyroid tumors

Properties

SIZE: entity length = 1664 aa MW = 178 kD COMPARTMENT: cell nucleus MOTIF: CREB1 & NRF1 interaction {433-467} proline-rich region SITE: 772-1137 MOTIF: proline residue (SEVERAL) CREB1 & NRF1 interaction {1379-1450} arginine-rich region {1400-1543} MOTIF: arginine residue (SEVERAL) serine-rich region {1411-1523} MOTIF: serine residue (SEVERAL) RNP motif NAME: RNP motif SITE: 1543-1619 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif

Database Correlations

UniProt Q5VV67 Pfam PF00076

References

UniProt :accession Q5VV67