peroxisome proliferator-activated receptor gamma coactivator 1-beta (PPAR gamma coactivator-1beta, PGC-1-related estrogen receptor alpha coactivator, PPARGC-1-beta, PGC-1-beta, PPARGC1B, PERC, PGC1, PGC1B, PPARGC1)

Function: 1) stimulates activity of transcription factors & nuclear receptors 2) activates transcritional activity of: estrogen receptor alpha nuclear respiratory factor 1 (NRF1) glucocorticoid receptor in the presence of glucocorticoids 3) role in constitutive non-adrenergic-mediated mitochondrial biogenesis 4) role in fat oxidation & non-oxidative glucose metabolism & in regulation of energy expenditure (putative) 5) interacts with HNF4A, SREBF1, PPARA, THRB, HCFC1, ESRRA, ESR1 Structure: - contains 2 LXXLL motifs, required for association with nuclear receptors contains 1 RRM domain (RNA recognition motif) Compartment: nucleus Alternative splicing: named isoforms=5 Expression: - ubiquitous - higher expression in heart, brain, skeletal muscle - repressed by saturated fatty acids, i.e. palmitate, stearate in skeletal muscle cells - induced by insulin Pathology: - expression diminished by aging in skeletal muscle biopsies - down-regulated in type 2 diabetes mellitus subjects & pre-diabetics Polymorphism: - variation of PPARGC1B may contribute to obesity Ala-203 allele is risk factor

Properties

SIZE: MW = 113 kD entity length = 1023 aa COMPARTMENT: cell nucleus MOTIF: Abolishes DNA transcriptional activity when missing {1-91} LXXLL motif 1 {156-160} LXXLL motif 2 {343-347} glutamate-rich region {430-450} MOTIF: glutamate residue (SEVERAL) HCFC1-binding-motif (HBM) {691-694} glutamate-rich region {772-823} MOTIF: glutamate residue (SEVERAL) RNP motif NAME: RNP motif SITE: 902-976 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif

Database Correlations

OMIM 608886 MORBIDMAP 608886 UniProt Q86YN6

References

UniProt :accession Q86YN6