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peroxisome proliferator-activated receptor gamma coactivator 1-alpha; PGC-1-alpha; PPAR-gamma coactivator 1-alpha; PPARGC-1-alpha; ligand effect modulator 6 (PPARGC1A LEM6 PGC1 PGC1A PPARGC1)
Function:
- transcriptional coactivator for steroid receptors & nuclear receptors
- greatly increases transcriptional activity of PPARG & thyroid hormone receptor on the uncoupling protein promoter
- can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis (putative)
- binds MYBBP1A, which inhibits it transcriptional activation
- interacts with PRDM16
- interacts with LRPPRC
- homooligomer
- interacts with LPIN1 (putative)
- induction of PPARGC1A expression by exercise results in
- secretion of irisin [2]
- white fat converting to brown fat
- increased insulin receptor sensitivity [2]
Structure:
- contains 1 RRM domain (RNA recognition motif)
Compartment: nucleus
Expression:
- heart, skeletal muscle, liver & kidney
- expressed at lower levels in brain & pancreas & at very low levels in the intestine & white adipose tissue
- in skeletal muscle, levels were lower in obese than in lean subjects
- fasting induces a 2-fold increase in skeletal muscle expression in obese subjects
- exercise induces skeletal muscle to produce PPARGC1A
General
RNA-binding protein
transcription factor (TF)
Properties
SIZE: entity length = 798 aa
MW = 91 kD
COMPARTMENT: cell nucleus
MOTIF: LXXLL {144-148}
PPARG interaction {293-339}
arginine/serine-rich region (RS domain) {566-599}
MOTIF: serine residue (SEVERAL)
arginine residue (SEVERAL)
arginine/serine-rich region (RS domain) {621-633}
MOTIF: serine residue (SEVERAL)
arginine residue (SEVERAL)
RNP motif
NAME: RNP motif
SITE: 677-753
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
NAME: ribonucleoprotein-1 motif
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
ribonucleoprotein-2 motif
ribonucleoprotein-2 motif
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
ribonucleoprotein-2 motif
Database Correlations
OMIM 604517
UniProt Q9UBK2
Pfam PF00076
Entrez Gene 10891
Kegg hsa:10891
References
- UniProt :accession Q9UBK2
- Bostrom P et al
A PGC1-alpha-dependent myokine that drives brown-fat-like
development of white fat and thermogenesis.
Nature. 2012 Jan 11;481(7382):463-8. doi: 10.1038/nature10777.
PMID: 22237023