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peroxisomal trans-2-enoyl-CoA reductase (TERP; HPDHase; pVI-ARL; 2,4-dienoyl-CoA reductase-related protein; DCR-RP; PECR)
Function:
1) fatty acid biosynthesis pathway
2) role in chain elongation of fatty acids
3) has no 2,4-dienoyl-CoA reductase activity
4) interacts with PEX5, probably required to target it into peroxisomes
acyl-CoA + NADP+ trans-2,3-dehydroacyl-CoA + NADPH
Structure:
- belongs to the short-chain dehydrogenases/reductases (SDR) family
Compartment: peroxisome
Alternative splicing: named isoforms=2
General
enzyme
Properties
SIZE: MW = 33 kD
entity length = 303 aa
MOTIF: cofactor-binding site [23-47]
COFACTOR-BOUND: NAD
binding site
SITE: 166-166
FOR-BINDING-OF: Substrate
tyrosine residue {Y179}
microbody-targeting signal {301-303}
Database Correlations
OMIM 605843
UniProt Q9BY49
Pfam PF00106
ENZYME 1.3.1.38
References
UniProt :accession Q9BY49