peroxisomal N1-acetyl-spermine/spermidine oxidase (polyamine oxidase, PAOX, PAO, UNQ1923/PRO4398)

Function: 1) flavoenzyme involve in polyamine catabolism 2) catalyzes oxidation of N(1)-acetylspermine to spermidine & is thus involved in the polyamine back-conversion 3) can also oxidize N(1)-acetylspermidine to putrescine 4) substrate specificity: N(1)-acetylspermine = N(1)-acetylspermidine > N(1),N(12)-diacylspermine >> spermine 5) does not oxidize spermidine 6) role in regulation of polyamine intracellular concentration 7) cellular sensitivity to antitumor polyamine analogs N(1)-acetylspermine + O₂ + H₂O N(1)-acetylspermidine + 3-aminopropanal + H₂O₂ Cofactor: FAD Structure: belongs to the flavin monoamine oxidase family Compartment: peroxisome, cytoplasm Alternative splicing: named isoforms=11 Expression: - widely expressed - not detected in spleen - induced by polyamine analogs Pathology: - expressed at lower level in neoplastic tissues

Properties

SIZE: MW = 70 kD entity length = 649 aa COMPARTMENT: cytoplasm MOTIF: microbody-targeting signal {647-649}

Database Correlations

UniProt Q6QHF9 Pfam PF01593 ENZYME 1.5.3.11

References

UniProt :accession Q6QHF9