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peroxisomal 2,4-dienoyl-CoA reductase (2,4-dienoyl-CoA reductase 2, pDCR, DECR2, PDCR)
Function:
1) auxiliary enzyme of beta-oxidation
2) degradation of unsaturated fatty enoyl-CoA esters with double bonds in both even- & odd-numbered positions in peroxisome
3) catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA
4) activity towards short & medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19-docosaheptaenoyl-CoA, suggesting that it does not constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid
Trans-2,3-didehydroacyl-CoA + NADP+
trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH
Kinetic parameters:
- KM=59 uM for 2,4-hexadienoyl-CoA;
- KM=6 uM for 2,4-decadienoyl-CoA;
- KM=102 uM for 2,4,7,10,13,16,19-docosaheptaenoyl-CoA;
Compartment: peroxisome
Alternative splicing: named isoforms=3
General
enzyme
Properties
SIZE: MW = 31 kD
entity length = 292 aa
MOTIF: cofactor-binding site [33-57]
COFACTOR-BOUND: NAD
microbody-targeting signal {290-292}
Database Correlations
UniProt Q9NUI1
Pfam PF00106
ENZYME 1.3.1.34
References
UniProt :accession Q9NUI1