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peroxisome assembly factor 1; PAF-1; peroxin-2; peroxisomal membrane protein 3; 35 kD peroxisomal membrane protein; RING finger protein 72 (PXMP3, PAF1, PEX2, PMP3, PMP35, RNF72)

Function: 1) biogenesis of peroxisomes 2) probably NOT PAF1 of PAF1 complex Compartment: peroxisomal membrane Pathology: - defects in PEX2 associated with a) Zellweger syndrome-1 b) infantile Refsum disease c) peroxisome biogenesis disorder complementation group 5

Related

peroxisome

General

peroxisomal membrane protein (peroxin) ring finger protein

Properties

SIZE: MW = 35 kD entity length = 305 aa COMPARTMENT: peroxisome MOTIF: transmembrane domain {140-159} RING-finger EFFECTOR-BOUND: Zn+2 FOR-BINDING-OF: DNA motif transmembrane domain {195-213} Zn finger C4-type SITE: 244-283 EFFECTOR-BOUND: Zn+2

Database Correlations

OMIM correlations MORBIDMAP 170993 UniProt P28328 PFAM correlations Entrez Gene 5828 Kegg hsa:5828

References

  1. UniProt :accession P28328
  2. GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=PXMP3