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peroxidasin homolog (vascular peroxidase, melanoma-associated antigen MG50, p53-responsive gene 2 protein) (PXDN KIAA0230 MG50 PRG2 VPO)
Function:
Donor + H2O2 oxidized donor + 2 H2O
Cofactor:
- binds 1 Ca+2 per subunit (putative)
- binds 1 heme B (iron-protoporphyrin IX) group covalently per subunit (putative)
Structure:
- belongs to the peroxidase family, XPO subfamily
- contains 4 Ig-like C2-type domain (immunoglobulin-like)
- contains 8 LRR repeats (leucine-rich repeats)
- contains 1 VWFC domain
Compartment: secreted (putative)
Alternative splicing:
- named isoforms=2
- additional isoforms seem to exist
Expression:
- expressed in heart, lung, ovary, spleen, intestine & placenta > liver, colon, pancreas, kidney, thymus, skeletal muscle & prostate
- a shorter form probably lacking the signal sequence is found in testis & in EB1 cells undergoing TP53/p53-dependent apoptosis
- expressed in fetal liver & spleen
- up-regulated in apoptotic cells
Pathology:
- expressed in tumors such as melanoma, breast cancer, ovarian cancer & glioblastoma
General
Ca+2 binding protein
enzyme
glycoprotein
melanoma associated antigen (MAGE)
secreted protein
Properties
SIZE: entity length = 1479 aa
MW = 165 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-26}
leucine-rich repeat
SITE: 61-84
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 85-108
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 110-132
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 133-156
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 157-180
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 182-204
MOTIF: leucine residue (SEVERAL)
immunoglobulin superfamily domain {246-332}
MOTIF: cysteine residue {C267}
MODIFICATION: cysteine residue {C317}
cysteine residue {C317}
MODIFICATION: cysteine residue {C267}
immunoglobulin superfamily domain {342-428}
MOTIF: cysteine residue {C363}
MODIFICATION: cysteine residue {C412}
cysteine residue {C412}
MODIFICATION: cysteine residue {C363}
immunoglobulin superfamily domain {433-520}
MOTIF: cysteine residue {C454}
MODIFICATION: cysteine residue {C502}
cysteine residue {C502}
MODIFICATION: cysteine residue {C454}
immunoglobulin superfamily domain {521-610}
MOTIF: cysteine residue {C546}
MODIFICATION: cysteine residue {C594}
cysteine residue {C594}
MODIFICATION: cysteine residue {C546}
N-glycosylation site {N640}
N-glycosylation site {N699}
N-glycosylation site {N719}
N-glycosylation site {N731}
cysteine residue {C732}
MODIFICATION: cysteine residue {C748}
cysteine residue {C748}
MODIFICATION: cysteine residue {C732}
heme-binding site [826-826]
histidine residue {H827}
Ca+2-binding site
SITE: 828-828
cysteine residue {C847}
MODIFICATION: cysteine residue {C857}
cysteine residue {C851}
MODIFICATION: cysteine residue {C875}
cysteine residue {C857}
MODIFICATION: cysteine residue {C847}
N-glycosylation site {N865}
cysteine residue {C875}
MODIFICATION: cysteine residue {C851}
Ca+2-binding site
SITE: 907-907
Ca+2-binding site
SITE: 909-909
Ca+2-binding site
SITE: 911-911
Ca+2-binding site
SITE: 913-913
cysteine residue {C959}
MODIFICATION: cysteine residue {C970}
cysteine residue {C970}
MODIFICATION: cysteine residue {C959}
arginine residue {977}
heme-binding site [980-980]
Iron [Fe]-binding site
SITE: 1074-1074
leucine-rich repeat
SITE: 1151-1175
MOTIF: leucine residue (SEVERAL)
cysteine residue {C1177}
MODIFICATION: cysteine residue {C1234}
N-glycosylation site {N1178}
cysteine residue {C1234}
MODIFICATION: cysteine residue {C1177}
leucine-rich repeat
SITE: 1270-1291
MOTIF: leucine residue (SEVERAL)
cysteine residue {C1275}
MODIFICATION: cysteine residue {C1301}
N-glycosylation site {N1280}
cysteine residue {C1301}
MODIFICATION: cysteine residue {C1275}
N-glycosylation site {N1368}
VWFC domain {1413-1471}
MOTIF: N-glycosylation site {N1425}
Database Correlations
OMIM 605158
UniProt Q92626
PFAM correlations
Kegg hsa:7837
ENZYME 1.11.1.7
References
UniProt :accession Q92626